Isolation and Identification of Bioactive Compound from Bacillus Megaterium from South East Coastal Region of India against Human Dental Caries
نویسندگان
چکیده
periodically, marine bacteria are producer of secondary metabolites in the harsh ocean. In this present study, a marine bacterium was isolated from marine cone snail in the Gulf of Mannar. The potential isolates was tested for various biochemical test and 16Sr RNA gene sequencing, which leads to their identification as Bacillus megaterium producing antibiotic compound for treating human diseases. Further, the selected isolates were cultured, purified and screened for antimicrobial activity against a battery of decay causing cariogenic pathogen Lactobacillus acidophilus. This pathogen were identified and analysed by Pg and Research Department of Zoology, Division of Microbial Technology, Chikkanna Govt. Arts College, Tirupur, collected from Fenn Dental Clinic in Tirupur District. Among these, 16 isolates exhibited strong bactericidal properties against tested pathogen Lactobacillus acidophilus. One promising strain, designated as MTBMVG07, with strong antimicrobial activity against cariogenic pathogen. Keywords— Antagonistic activity, Bacillus megaterium, Dental caries, L. acidophilus and Secondary metabolites.
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